The main aim of the present study was “In vivo study of self-emulsifying drug delivery system (SEDDS)”.Ex-vivo drug release study of optimized formulation was performed using male albino rat skin. The rat epidermis was mounted onto a Franz diffusion cell in such a way that the dermis side was in contact with receptor solution. Freshly excised abdominal skin was used for ex-vivo studies, whose hair had been previously removed. The permeation profiles were constructed by plotting the cumulative amount of amlodipine permeated per unit rat skin area (μg/cm2) versus time.The anti-inflammatory activity of prepared ibuprofen SEDDS was evaluated by the carrageenan-induced rat hind paw edema method.

In vivo, anti-inflammatory activity, permeation activity.