Volume 20 No 22 (2022)
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IN-VITROESTIMATION OF ANTIOXIDANT AND ANTIDIABETIC POTENTIAL OF PLANT EXTRACTS
DIPALI P. SHELKE , VIJAYENDRA SWAMY M
Abstract
Medicinal plants have always been the principal sources of medicine worldwide. India sustains a very rich traditional medicinal plant wealth and inherits unique plant and animal communities. Free radicals are implicated in many diseases like diabetes, inflammation, cancer, which leads to gained more attraction of antioxidant therapy. Diabetes is a metabolic disorder which results due to deficiency in insulin and its metabolism. At present, the prevalence of Diabetes has increased worldwide and predicted to increase to greater extent in future generations. Among various therapeutic approaches implemented to prevent diabetes is to regulate the blood glucose levels by various mechanisms. Present study enumerates the In-Vitro Evaluation of Antioxidant and Antidiabetic Potential of Plant Extracts. Phytochemical screening showed the presence of alkaloids, glycosides, carbohydrates, steroids and flavonoids in both the extracts. Physical parameters like solubility, MP, ash values, LOD, extractive value etc. has been studied. The antioxidant activity of the extract was done by using DPPH and H2O2 method. This is being assessed by assay such as inhibition of α-amylase enzyme suppresses the level of production of glucose. Our results suggested that D. strictus extracts showed potential In-Vitro antioxidant and anti-diabetic activity which indicates that this extract can be taken further for pharmacological study.
Keywords
D.strictus, Physicochemical parameter,Antioxidant effect, Anti-diabetic activity, α-amylase enzyme.
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