Bone sarcomas, particularly osteosarcoma, pose a significant challenge due to their aggressive nature and resistance to conventional therapies. Nanotechnology-based approaches have gained attention for their potential in cancer treatment. In this study, we investigate the anti-cancer activity of epoxy-nano silica-thermoplastic starch (ENT) composites against human bone sarcoma cells. The nanocomposites were synthesized and characterized for their physicochemical properties, including surface morphology, and biocompatibility. Their cytotoxic effects were evaluated using MTT assay to determine cell viability and mechanisms of action. Results demonstrated that ENT composites exhibited significant cytotoxicity against bone sarcoma cells, inhibiting proliferation in a dose-dependent manner. These findings suggest that ENT composites hold promise as a novel therapeutic strategy for bone sarcoma treatment and warrant further in vivo studies to assess their clinical potential.

Nanocomposites, bone sarcoma, osteosarcoma, nanotechnology, anti-cancer activity