Musculoskeletal Diseases (MSDs) is the most common occupational health problem and affect workplace employees which MSDs are increasing in Iran. This study aimed to identification of the factors predicting the Stretching Exercise (SE) behavior among Office employees with reinforcing and developing the performance of the Health Promotion Model (DHPM) in Shahid Beheshti University of Medical Sciences (SBUMS) of Iran. This cross-sectional study, data were collected a questionnaire-based on HPM for SE behaviors and Self-Regulation, Counter-conditioning, and Stimulus control questionnaire (DHPM) From eligible 385 office employees working in comprehensive service centers for urban-rural health affiliated to SBUMS, selected by Multistage cluster sampling from May to Sep 2017. All structures were examined as predicting factors to decide whether or not they affect the likelihood of the prevalence of SE behavior. The data were analyzed using Confirmatory Factor Analysis the method by Amos software 22 and regression analysis with SPSS 19 software. Totally 385 office employees with mean age of 39.4±7.76 years old took part. The effects of the validity of two versions of HPM (RMSEA= 0.067, x2/df=2.98, GFI&CFI=0.90) and DHPM in confirmatory factor analysis confirmed that fitness Indexes of the DHPM (RMSEA= 0.059, x2/df=2.38, GFI&CFI=0.97) were better. Regression analysis reflected that the coverage ratio of SE behavior variance of the DHPM is more than the HPM. This study showed that perceived barriers to action could prevent the studied participants from engaging in stretching exercise. Perceived self-efficacy, Commitment to a plan of action, interpersonal influences, and Stimulus control were significant predictors for SE behavio

health promotion, exercises, musculoskeletal, sedentary lifestyle, occupational health