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Volume 18 No 2 (2020)
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Impact of Mangosteen Rind on TNF-α Level of Diabetic Wound Healing
Lanny Sunarjo,, Oedijani, Suharti, Henry Setyawan Susanto, Diyah Fatmasari
Abstract
Experiment with randomized pre-post test with control group design. Sample was 40 male Wistar rats aged 8-10 weeks, weight 120-160 g, divided into 4 groups: diabetic wound treated MRE; diabetic wound control; nondiabetic wound treated MRE and non-diabetic wound control. Preparation of type 1 diabetic rats using induction of Streptozotocin (STZ) 1x with dose of 50 mg/kg intraperitoneal. Rat with diabetes when blood glucose at fasting time (hyperglycemia) ≥ 250 mg/dl. Diabetic wound was made by extraction of right upper incisor, as well as in nondiabetic wound. Monitoring of diabetic wound healing was by TNF-α level in inflammatory phase. Data was analyzed by General Linear Model test.
Keywords
Male Wistar Rat, Mangosteen Rind, Diabetic Wound Healing, TNF-α.
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