Human Spaceflight has been shown with deleterious changes in knee joint including Loss of muscle mass & strength, Reduced Functional capacity, Increased Fatigue level , demineralization, Changes in connective tissue, degradation of collagen II network in articular cartilage following proteoglycan degradation and ultimately lead to joint instability. Antigravity muscles are commonly involved such as leg extensors. The mechanism of these changes are not fully understood but can be attributed to muscle usage. Emphasis will be placed on knee extensor and plantar flexor muscles known to be particularly susceptible to deconditioning in space missions .Therefore, Human spaceflight ( Pre-Flight, Mid-Flight & Post-flight ) Physiotherapy & Conditioning Regimes should be considered for knee joint such as specially integrated resistance training , Treadmill training and Cycle ergometer.

Knee Extensors, Flight Rehabilitation, Integrated Resistance Training, Treadmill training, Cycle ergometer