Central nervous system (CNS) depressants are drugs that calms down the CNS. These drugs are used for the treatment of anxiety and seizure. GABA is the principal inhibitory neurotransmitter of the central nervous system. CNS depressants brings about their effects by acting on the GABAA receptors of the Central nervous system. In Siddha system of medicine, mental illness is mentioned as “Brammai”. Pancha karpa mathirai is the Siddha herbal formulation widely used for mana noigal (psychiatric illness). Thus, the present study was undertaken to evaluate the Pancha karpa mathirai against the GABAA receptor through in-silico approaches. Docking calculations were carried out for retrieved phytocomponents against target GABA- A receptor by auto dock program. Total of 10 bioactive lead compounds were retrieved from the herbs, from the reported data of the herb, the phytochemical Chebuloside possess 3 interactions out of 4 target core active amino acid residues present on the GABAA receptor which signifies 75% of the binding efficacy. Thereby it was concluded that these compounds may exert promising anxiolytic and anti-convulsant activity.

Anxiolytic, anti-anxiety, panchakarpa mathirai, docking study, Siddha.