As the incidence of microbial infections and antimicrobial resistance increases day by day there is a need for new anti-microbial agents, which has become global concern now a days. Polysaccharides have much importance because of their therapeutical potential against wide range of infectious diseases. The aim of present study is to determine the antimicrobial potential of N-Acetyl -DGlucosamine by using in vitromethods.N-Acetyl D-glucosamine was subjected for screening of antimicrobial activity against various strains of bacterial species, Methicillin Resistant Staphylococcus aureus (MRSA), Bacillus subtilis, Salmonella typhimurium and Escherichia coli, using standard protocol of disc diffusion method (DDM) and well diffusion method. The antibacterial activities were determined by the zone of inhibition and MIC (Minimum inhibitory concentrations) values. The significant antibacterial activity of N-Acetyl-D-glucosamine was determined and compared with the standard antimicrobial agent Gentamicin (0.01mg/ml). The results obtained in the present study suggest that NAG can be used for treatment of various diseases caused by the test organisms used in this study.

NAG (N-Acetyl-D-Glucosamine), anti-microbial resistance, polysaccharides, MIC, Zone of inhibition. DOINumber: 10.4