The sixth most common cancer in women worldwide is ovarian cancer. Ovarian cancer claims the lives of more women each year than any other condition affecting the female reproductive system. It is the most deadly cancer of the female reproductive system and the fifth greatest cause of cancer-related fatalities. It also has the highest mortality rate among gynaecologic cancers. The current study assists in determining the impact of benzophenone and pyrazine derivatives on ovarian cancer Insilico on Janus kinase-signal transducer. The binding modes of two molecules are predicted via computational docking. The protein human JAK STAT's 3D structure was obtained from the protein data bank . Binding affinity characteristics were identified in Auto Dock and were compared to the standard Paclitaxcel. The benzophenones molecule showed the highest binding affinity with JAK STAT (-7.6). The paclitaxcel molecule showed the binding affinity with JAK STAT (-7.7). Chloropyrazine showed the binding affinity with JAK STAT (-3.7).

Ovarian cancer, Benzophenone, Pyrazine, PyRx 0.9, Janus kinase, Auto Dock