Introduction Neuropathic pain (NP) is a chronic condition affecting millions worldwide, often leading to poor quality of life. Conventional pharmacological treatments provide limited relief and are associated with adverse effects. Personalized multimodal physiotherapy, which tailors interventions to patient-specific factors, offers a promising alternative for optimizing NP management by addressing the physical and psychological components of pain. Methods This prospective cohort study included 150 NP patients randomized into two groups: personalized multimodal physiotherapy (n=75) and standard care (n=75). The personalized group received interventions such as exercise therapy, manual therapy, transcutaneous electrical nerve stimulation (TENS), and cognitive-behavioral therapy (CBT) based on individual clinical profiles (age, comorbidities, and pain duration). The control group received general physiotherapy. Primary outcomes were pain intensity (Numeric Pain Rating Scale [NPRS], Visual Analog Scale [VAS]) and functional status (Patient-Specific Functional Scale [PSFS], Brief Pain Inventory [BPI]). Secondary outcomes included psychological well-being (Hospital Anxiety and Depression Scale [HADS], Pain Catastrophizing Scale [PCS]) and quality of life (SF-36, EQ-5D). Outcomes were measured at baseline, 6 weeks, and 12 weeks. Results At 12 weeks, the personalized group showed a significant reduction in pain intensity (NPRS: -4.7 vs. -1.6, p < 0.001; VAS: -43.2 vs. -12.6, p < 0.001) and greater improvements in functional status (PSFS: +4.1 vs. +1.2, p < 0.001; BPI: -3.4 vs. -1.1, p < 0.001). Psychological well-being improved by 40% in anxiety and 52% in depression (HADS) in the personalized group, along with significant improvements in quality of life (p < 0.001). Conclusion Personalized multimodal physiotherapy significantly improves pain, function, and psychological well-being in NP patients. Tailoring interventions based on individual profiles offers an effective, non-pharmacological approach to NP management.

Neuropathic pain, personalized physiotherapy, multimodal therapy, cognitive-behavioral therapy, pain management, quality of life.