Volume 20 No 20 (2022)
 Download PDF
Invitro Anticancer Activity Of Curcuma Amada Against Human Breast Cancer Cell Line Mcf-7
Prasanthi Donipati, Dr. S. Hara Sreeramulu, Prasanna Jyothi Donipati,N.M.Yugandhar
Abstract
Use of naturally occurring herbs and spices for inhibiting the growth of cancer cells are gaining considerable attention from scientific community due to its low-cost, non-toxicity and high efficacy. Cellular extract of these herbs and spices contains different phytochemicals and bioactive compounds which have shown remarkable inhibition ability for various kinds of cancer cell lines. Herein, we have explored the extract of Curcuma amadaRoxb in different organic solvents (hexane, chloroform and methanol) for evaluating their cytotoxicity against human breast cancer cell lines (MCF-7) which belongs to family Zingiberaceae used in conventional system of medicine. This important spice is generally used in the preparation of different sauces, pickles, salads and jams. Curcuma amada is well known for its anti-inflammatory, antioxidant, and antitumor properties. The main aim of the present work is to investigate the in vitro anticancer activities of the hexane, chloroform and methanolic extracts of Curcuma amada against the human breast cancer cell lines [MCF-7]. The average values of (Hexane, Chloroform and Methanolic concerntrations) Curcuma amada on the mortality of MCF-7 cells revealed that the Chloroform was more potent than (10:62.9, 20:32.1, 40:3.0, 80:31.5) than Hexane and Methanolic concerntrations. The toxicity of different concentrations of Curcuma amada was also investigated against MCF7 cell lines (Hexane, Chloroform and Methanolic concerntrations) which corroborated the potential results. In the present study, Methanol treatment on cell growth of drug-sensitive and Adriamycin-resistant MCF-7 cells where, maximum inhibition was observed.The plant extractinvestigated in this study have significant anticancer activity against the breast cancer cell lines tested. Further investigation is required to isolate and elucidate the structure of the compounds responsible for the observed activity.
Keywords
Curcuma amada, breast cancer, anticancer activity, hexane, chloroform and methanol.
Copyright
Copyright © Neuroquantology

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in the Neuroquantology are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJECSE right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.