Volume 17 No 2 (2019)
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LQR Suppression of Hopf Bifurcation in HodgkinHuxley Neurons
Yexin Lin, Haiyuan Liu and Li Hu
Abstract
The work of Hodgkin and Huxley on nerve conduction has long been recognized as an outstanding scientific
achievement. The Hodgkin-Huxley equations are modeled by a number of parameters and perform diverse behaviors
depending on the various parameters. The purpose of this research is to solve the bifurcation control problem in
the Hodgkin-Huxley nerve fibers. In this study, we focus on the Hopf bifurcation in the HH model, which arises by
the external current injection. We present a feedback controlled approach to control the bifurcation phenomenon
in the Hodgkin-Huxley nerve fibers via washout filter which can stop the repetitive firing in a particular region of
the nervous system validly. A washout filter is augmented to the HH dynamics and the output of the filter is fed to
an external controller generator through a linear gain. The linear projective control theory is applied to compute the
control gain. The stable controller is performed by two similar control rules that are designed by the integration of the
washout filters and static projective control theory. The first case of the control rule filters all the dynamic variables
including the membrane potential and the channel activation, while the second case of the control rule filters merely
the membrane potential. The MATCONT software package is used for analysis of the bifurcation points in conjunction
with MATLAB
Keywords
Hodgkin-Huxley model, Hopf bifurcation, Washout filter, Bifurcation control
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