In this article we present the mathematical formalism of Quantum Zeno Effect (QZE) and explain how the QZE arises from suppression of coherent evolution due to external strong probing action. Then we prove that the model advocated by Henry Stapp, in which mind efforts are able to exert QZE upon brain states, is not robust against environmental decoherence if the mind is supposed not to violate the Born rule and to act only locally at the brain. The only way for Stapp to patch his proposal would require postulation of mind efforts acting globally on the brain and the entangled environment, which would be regression to a theory predicting paranormal Psi effects. Our arguments, taken together with the lack of scientifically valid confirmation of paranormal Psi effects such as telekinesis, imply that Stapp’s model does not have the potential to assist neuroscientists in resolving the mind-brain puzzle

Quantum Zeno Effect, mind, brain, Stapp’s interactive dualism, decoherence