


Volume 20 No 20 (2022)
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NEUROPROTECTIVE POTENTIAL OF FLOWERS OF NYCTANTHES ARBOR-TRISTIS ON ALUMINIUM CHLORIDE INDUCED NEGATIVE EFFECTS ON LEARNING ABILITIES IN RATS.
Arvind B. Naik , Deepti Bandawane
Abstract
This study investigated the neuroprotective effects of Nyctanthes arbor-tristis flower on memory and learning in aluminium chloride-induced brain dysfunction in rats. All Wistar rats in groups III and IV received the treatment dosages (100 and 200 mg/kg) 30 minutes prior to the oral administration of aluminium chloride (100 mg/kg), which was given every day for 42 days. The overall behavioural activity of rats was assessed using an open field arena (OFA) on days 20, 21, and 42 after the beginning of the administration of aluminium chloride. The parameters viz. line crossing, centre square entries, rearing, and grooming were used to score behavioural performance. Morris Water Maze (MWM) and the Elevated Plus Maze(EPM) were used to assess cognitive performance. In MWM- rats were trained on day 19 and 20 to swim to a platform in a circular pool. The acquisition latency—the time it takes to get to the visual platform was measured. The first retention latency (1 RL) (21 day) and the second retention latency (2 RL) (42 day) were measured as the amount of time it took to identify the hidden platform,counted from the first day of aluminium chloride administration. On day 20, for EPM rats were trained, and each rat was placed at the end of an open arm. The initial transfer latency(ITL), which measures the time it took the rat to go from the end of the open arm to either of the closed arms, was then recorded. The rats were examined for retention latency on days 21 and 42, and the results were referred to as first RTL and second RTL, respectively. The respective treatment groups (100/200 mg/kg, p.o.) significantly defended against aluminum- induced brain damage, as evidenced bythe neuroprotective potential of Nyctanthes arbor-tristis.
Keywords
Nyctanthes arbor-tristis, Neuroprotective potential, cognitive performance
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