Volume 20 No 20 (2022)
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Nickel Oxide NPs as a Catalyst in Diastereoselective Aldolization of Heteroaromatic aldehydes
Elahe Keshavarz
Abstract
A fast and diastereoselective protocol was developed for the synthesis of aldol derivatives in the presence of a catalytic amount of nickel oxide nanoparticles at room temperature. Aldol adducts were obtained in moderate to good yields and complete diastereoselectivities in short reaction times. In this method, heteroaromatic aldehydes readily participate as electrophilic cross aldol partners with a range of cycloalkanones as ketone donors.
Keywords
Aldolization, Nickel Oxide NPs, Heteroaromatic aldehydes
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