Comparative study of ionic gelation & spray dry methods for preparation of microspheres to deliver drugs has many other advantages over one another, like control-release of the drug, increase bioavailability and target delivery of the drug to the required site. In this research work shows the use of encapsulating sodium alginate, sodium carboxy methyl cellulose in biodegradable microsphere delivery system, to be delivered orally via a capsule, to gives desired therapeutic action. Microsphere formulations have merits over conventional tablet or capsule formulations, since it increases the surface area exposed to the absorption site and thus increasing the absorption of the drug and decreasing the dosing frequency of the drug. Flurbiprofen is a NSAIDs which is used widely in different intestinal diseases ulcerative colitis, Crohn’s disease, carcinomas and infections. Flurbiprofen shows maximum absorption in the lower gastrointestinal tract regions, and shows half-life 4 hrs, it shows low bioavailability orally. The microsphere formulations were evaluated for its production yields, actual drug content, encapsulation efficiency, % Swelling Index release study is done by in vitro release analysis, mucoadhesive strength determination in vitro & in vivo methods.

Mucoadhesive, Microsphere, Flurbiprofen