d:Psoriasis is an autoimmune and inflammatory skin disease affecting 2–4% of the global population. The pathogenesis of psoriasis is far from being elucidated. Psoriasis comorbidities constantly lead researchers to look for their newer predictive markers. Selenoproteins are produced in the liver and involved in defense against oxidative stress by taking part in oxidation-reduction reactions neutralizing reactive oxygen species (ROS). It is worth mentioning here that oxidative stress closely related with inflammation participates in the development of pathological processes in psoriasis. Selenoproteins may improve immune response, thanks to their anti-inflammatory, chemo preventive and antiviral properties. Many disorders seem to be related to selenoprotein metabolism, such as cardiovascular, endocrine, immune and neurological diseases.Selenoproteins has recently become a particular object of studies on its potential use as a predictor or biomarker of different disease prognosis, pointing to the divergent actions of SeP or even promoting the development of some diseases. The elevated concentration of SeP was reported in various cardiometabolic disorders, such as obesity, DM, non-alcoholic fatty liver disease and CVD, all closely related to psoriasis

Psoriasis, Selenoproteins, Pathogenesis; Clinical applications