The objective of the presented work was to evaluate the film forming property of sago starch and formulate a film for the delivery of drug in the oral cavity. In the present research we also evaluated the effect of water soluble drug (levocetirizine dihydrochloride) and water insoluble drug (famotidine) on the properties of sago starch bases oral film. The formulations were prepared using semisolid casting method. The starch dispersion was pregelatinized at 90 0C before casting into films. Films were dried at 50 0C. A full 32factorial design was applied and 9 batches for each drug (L1-L9) for levocetirizine dihydrochloride and F1-F9 for famotidine) were formulated. The two independent variables selected were concentration of sago starch (X1) and heating time of starch dispersion at 90 0C (X2). The formulated films were evaluated for various parameters. Scanning Electron Microscopy study of the films was also performed and it was observed that the film containing water insoluble drug was having rougher surface and there were a large number of micro cracks were present. Thus it can be concluded that sago starch can be used as a film forming agent for the delivery of drug whether soluble/insoluble in the oralcavity.

oralcavity, levocetirizine dihydrochloride, famotidine, Gelatinized Sago Starch, Oral Film