Volume 22 No 1 (2024)
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Performance of Serum Superoxide Dismutase as a Prognostic Marker in Acute Traumatic Brain Injury Patients from Northern India and Its Clinical Outcome
Mohammad Tabish Khan, Seemin Azmat, Mohd Musheer Altaf, Rehman Hyder, Mohammad Ahmed Ansari, Raman Mohan Sharma, Kulwant Singh
Traumatic brain injury ( is primarily based on a clinical assessment, neurological examination and radiological imaging. Tools for diagnosis and risk stratification of intracranial injury are limited in emergency department. In emergency setting, main stay of treatment begin with clinical evaluation which include symptom, Glasgow Coma Scale (GCS), neurologic examination along with the radiological assessment by Computed Tomography Scanning and Magnetic Resonance Imaging. Long term neuropsychological dysfunction is known to occur in majorityof patients with intracranial injury even without radiological evidence. This fuels the need to identify tests which may guide in reducing the sequelae of TBI. Such test may play an important role in under diagnose case with mild TBI, in severe TBI with risk of secondary brain insult, and assessing patient status at peripheral center where immediate neurosurgical facilities are not available. In this study we investigated the role of serum superoxide dismutase as a prognostic markerand outcome of acute traumatic brain injury. The SOD levels were correlated with outcome at discharge in both the mild and severe TBI. Good outcome was defined as Glasgow Outcome Scale (GOS) score 4 and 5, and poor outcome group with GOS score 1, 2, 3. In the mild TBI group serum SOD protein levels in the good outcome group were not significantly higher compared to the poor-outcome group. Thus SOD may prove to be a significant prognostic marker in severe TBI.
Serum Superoxide Dismutase; Traumatic brain injury; Glasgow Coma Scale; Computed Tomography Scanning; Magnetic Resonance Imaging
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