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Volume 20 No 8 (2022)
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Phytochemical screening and anti-venom effect of leaves extracts of Andrographis paniculata and Morus alba
Dinesh Jindal Raghvendra S. Bhadauria
Abstract
It is estimated that the true incidence of snake envenomation could exceed 5 million per year.
About 1,00,000 of these develop severe squeal. The present study aims to study the anti-snake venom
activities of the local plants, which are native to the western ghats of India. These plants were found to
be used by traditional healers in Maharashtra, India to treat patients bitten by snakes. Andrographis
paniculata plant extracts and incubated at 37°C for 30 minutes prior to injection. We found that 0.15- 0.17
mg of Andrographis paniculata plant extracts were able to completely neutralize the lethal activity of
2LD50 of V. russelli venom and 0.16-0.19 mg of Andrographis paniculata plant extracts were able to
completely neutralize the lethal activity of 2LD50 of Najanajavenom and 0.14-0.18 mg of Morus alba plant
extracts were able to completely neutralize the lethal activity of 2LD50 of V.
Keywords
phospholipase Andrographis paniculata, antivenom activity, Morus alba Najanaja, D. russelli venom,
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