


Volume 20 No 16 (2022)
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Phytochemical screening and in vivo antioxidant activity of Plumeria alba leaf extracts in Streptozotocin-nicotinamideinduced diabetic rats.
Jyoti Nanda , Munesh Mani, Shanti Bhushan Mishra , Neeraj Verma
Abstract
Plants have long been a key source of medicines in the Indian medical system. This alternative system of
medicine is gaining popularity worldwide. In Ayurveda, Charaka Samhita, and Sushruta Samhita, it is
mentioned that some Plumeria species have therapeutic significance in the treatment of certain human
maladies. Plumeria alba Linn., an Apocynaceae-related plant, is a common component of perfumery and a
traditional medical treatment for a variety of illnesses. Several chemicals found in plants, including
glycosides, alkaloids, terpenoids, flavonoids, steroids, phenols, carbohydrates, proteins, and amino acids,
have important and diverse pharmacological effects that can treat a wide range of diseases and disorders.
In the current study, the antidiabetic potential of Plumeria alba was investigated by producing diabetes in
experimental animals by inducing diabetes through a single dose of STZ (60 mg/kg) after the
administration of nicotinamide (120 mg/kg). In the treatment protocol, ethanolic and aqueous leaf
extracts at 250 mg/kg b.w. and 500 mg/kg b.w. given orally for 21 days and the effect on blood sugar
levels was measured. In comparison to the diabetic control group, the ethanolic extract at a dose of 500
mg/kg b.w. exhibits a highly significant (p<0.001) reduction in blood glucose levels. The results of the
biochemical examination indicate the ethanolic extract's anti-diabetic activity against chemically induced
diabetes by estimating the levels of blood cholesterol, triglycerides, high-density lipoprotein, and lowdensity lipoprotein. Additionally, it was discovered that the in vivo antioxidant biomarkers GSH, GST, GPx,
and CAT in the liver and kidney indicate decreased oxidative stress when compared to the diabetes control
group. According to the results of the current investigation, it was indicated that Plumeria alba exhibits
remarkable action against oxidative stress-linked diabetic conditions.
Keywords
Antidiabetic, Oxidative stress, Plumeria alba, Phytochemicals, hypolipidemic
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