Polymorphisms of TLR 8 by Tetra- ARMS Technique Associated with COVID-19 Patients of Ira

Volume 20 No 8 (2022)

Zahara Ali AbdAl_Ameer and Kawther M. A. Hasan

DOI: 10.14704/nq.2022.20.8.NQ44645

Abstract

The clinical spectrum of COVID-19 is extremely variable. Thus, it is likely that the heterogeneity in the genetic make-up of the host may contribute to disease severity. Tolllike receptor (TLR)8 plays a vital role in the innate immune response to SARS-CoV-2 infection. We genotyped 60 adult COVID-19 samples taken from 20 patients, 20 recovery persons and 20 healthy people for TLR8 (rs3764880 A/G) polymorphisms usingTetra- ARMS Technique. The frequency of alleles of TLR8 gene polymorphism of A allele is 57.5% in patients and 60.0% in control group, while frequency of G allele is 42.5% in patients and 40.0% in control group. While, the frequency of alleles of TLR8 gene polymorphism of A allele is 55.0% in recovery and 60.0% in control group, while frequency of G allele is 45.0% in recovery and 40.0% in control group.

Keywords

COVID‐19, cytokines, SARS‐CoV‐2, Toll‐like receptors

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