Phytoconstituents have low permeability, solubility compared to that of synthetic drugs. The objective of the present study is to improve permeability, solubility of phytoconstituents of Ginkgo by combining them with phospholipids and preparing it as phytosomes. Ginkgo biloba is natural drug which contains has two active components. Terpene lactones (ginkgolides and diterpenes) and flavone glycosides (ginkgetin, bilobetin, and sciadopitysin) 1 are the major active chemical constituents. The Ginkgo phytosomes were formulated by using rotary evaporator method. The formulations of phytosomes were analyzed for scanning electron microscopic analysis, particle size, zeta potential, drug content, drug entrapment efficiency, percentage yield and in-vitro drug release. The Release kinetics of Ginkgo phytosome complex2 was studied using kinetic models. The Ginkgo phytosome formulation containing drug to phospholipid ratio of 1:2, i.e., Formulation F-4 exhibited greater practical yield, drug content, drug entrapment efficiency, less particle size & higher zeta potential and best in-vitro drug release of drug. Formulation F-4 had shown enhanced solubility and better compatibility with the excipients. Therefore it is concluded that Ginkgo phytosomes have good permeability to cross lipid-rich biological membranes and better solubility than that of the Ginkgo drug alone. Phytosomes are able easily compared to drug alone

Ginkgo, Ginkgo phytosome complex, Soy lecithin