Stearic acid nanoparticles loaded with Aripiprazole has been developed as a new therapeutic strategy to achieve its controlled release profile suitable for parenteral administration. Nanoparticles composed of different stearic acid ratio and drug composition were synthesized and loaded with aripiprazole by melt emulsification and low temperature solidification. The melting point of the drug was found to be 176o C. The solution of aripiprazole in PBS (pH 7.4) was scanned in the range of 200-400 nm using SYSTRONICS 2202 UV/visible spectrophotometer. The max was found to be 254 nm in PBS (pH 7.4). In order to estimate aripiprazole in experimental protocol, standard curve of drug was prepared in distilled water at 254 nm. Partition Coefficient of drug in n-Octanol/water was found to be 3.66. Subsequently evaluation by Samples with very broad size distribution have polydispersity index values > 0.7, particle size determination 277.22± 20, exhibit size range in between 50-1000 nm,the coated samples were then randomly scanned using a scanning electron microscope (SEM JSM-6510LV). and photomicrographs were taken., Nanoparticles was to be found 25.72± 2.3 to 30.19± 1.6, Data of PDI were found more than 0.7 for all formulation, Percentage yield was obtained in the range of 49.07 to 74.67 determined, In vitro drug release (94.11±1.88) , zeta potential.72± 2.3 to 30.19± 1.6, maximum entrapment efficiency79.45.

Stearic acid, Aripiprazole, Melt emulsification and low temperature solidification, Nanoparticles