In current research work, we prepared a nano-based system for targeted drug delivery in which the drug is encapsulated into activated folic acid attached bovine serum albumin nanoparticles the drug for choice is celecoxib which is useful in rheumatoid arthritis disease. In this work, we first prepared the nanoparticle which is used for further study and we found that the nanoparticle is successfully prepared and has having very suggestive size range and zeta potentialThe mean size of BSA-CELECOXIB and FA-BSA-CELECOXIB nanoparticles was observed to be 105±6 and 148.7±9 nm along with ζ-potential value of -15±1.3 and -10.4±1.7 mV and pdi1±0.2 and 1±0.5, respectively it is also have very good stability profile percentage residual drug in nanoparticles formulation BSA-CELECOXIB was found to be 85.37 when stored at 4±2 °C and 70.54%when stored at 37±2 °C and 74.23% which suggest the research work for further studies.

Encapsulated, Bovine serum, Nanoparticles,Zeta potential, Stability.