Background: Hypogonadism is a biochemical and clinical illness that correlates with reduced concentrations of testosterone in adult males. This syndrome can have a negative impact on the functioning of many organs as well as the life quality to a signifsicant degree. There is a great connection between it and the progression of diabetes. The purpose of this research to investigate the prevalence of hypogonadism and the risk factors associated with it between men who have type 2 diabetes (T2D). Patients and methods: The investigation included an overall of 300 men who had been identified with type 2 diabetes and ranged in age from thirty to seventy years old. For the purpose of determining the level of androgen deficient in males, an Arabic version of the Androgen Deficiency in Aging Male (ADAM) questionnaire has been utilized. With the use of enzyme immunoassay, we have been assessed to determine the concentrations of hemoglobin FSH, LH, A1c, total in addition to free testosterone. Results: individuals diagnosed with type 2 diabetes have been separated into 2 groups: forty-eight individuals’ sixteen percent had hypogonadism, while 252 cases eighty-four percent didn't have hypogonadism. After conducting a numerous logistic regression analysis to detect the factors that impact hypogonadism in cases based on their total testosterone and ADAM levels, it has been discovered that Hb A1c, age, body mass index (BMI), in addition random blood sugar are independent risk factors for the development of hypogonadism. The odds ratio for these factors was 0.95, 1, 1.1, 1.37, and the p value for each of these factors was 0.02, 0.03, 0.03, and 0.008 correspondingly. The ROC study of cut off values and the accuracy of indices for the total testosterone that was considered for the purpose of predicting hypogonadism based on the total testosterone plus Androgen Deficiency in Aging Male score being positive: The AUC was 0.98, with a p-value of less than 0.0001. The sensitivity was one hundred percent, and the specificity was 96.4 percent, when the cutoff value was equal to or less than twelve. The conclusion is that hypogonadism has a strong association with a number of potential variables that are correlated with diabetes. Between men diagnosed with T2D, the development of hypogonadism is independently associated with body mass index, age, HbA1c, in addition blood sugar.

Hypogonadism; T2D; ADAM.