The traditional thoughts hold that action potential is a basis of neural information transmission. Previous studies have found that microtubules are structurally connected to some ion channels such as the subunits of sodium, potassium and calcium channels on axons, suggesting that microtubules may be related to the propagation of action potential. Moreover, recent studies have demonstrated that microtubule system network in the brain may be involved in the mechanism of photon quantum brain and the origin of consciousness. These studies indicate that the structural integrity of microtubules is closely related to the action potential. However, the detailed relationship between microtubules and action potential is not clear. Here, we found that the compound action potentials of bullfrog sciatic nerve were inhibited significantly by colchicine, a microtubule depolymerizer. The inhibitory effects presented time-dependent changes and even reached to a decrease of 57% after treatment for 480 min with 20 mM Colchicine. These results suggest that the propagation and transmission of action potentials are related to the stability of microtubule system and may involve in the neural quantum mechanism

action potential, microtubule, sodium channels, neural quantum mechanism