Background : Spinal cord injury (SCI) is a traumatic event that results in disturbances to normal sensory, motor, or autonomic function and ultimately impacts a patient’s physical, psychological, and social well-being.It is a major public health issue in India. Appropriate planning is needed for prevention , rehabilition and psychological care for SCI patients. Objective: To assess the health-related quality of life of patients with traumatic spinal cord injury living in Eastern India. Methods: The present study was a prospective observational study carried out at Tertiary Trauma Care Centre, IPGME&R and SSKMH, Kolkata in Eastern India. A total of 150 patients with Spinal cord injury patients admitted in our institute during a period of 1 year (04/03/2020 to 04/03/2021) were included in study. After written informed consent the following variables were recorded in all patients: Age and sex distribution, marital status , education , duration and nature of symptoms, whether an operation required or not , postoperative surgical outcome and complications, length of ICU/CCU stay , length of hospital stay .The clinical follow-up observation was carried out by outpatient review. The patients were followed up at 6 months after discharge. All the data was recorded in a pre-designed and pre-tested proforma and WHOQOL-BREF questionnaire. Results: Present study showed no statistically significant differences in mean values of quality of life with respect to age, sex, marrital status and Comorbidity. However, a significant difference in quality of life was found in the patients with respect to level of education , complication such as UTI, Bed sore, spasticity , Length of stay in ICU with QOL ,need of Airway/Mechanical ventilator(MV), vasopressor support, ASIA grade and Region of spine injury. Conclusion: HRQoL is decreased in SCI patients. Health related QoL in different domain Physical health ,Psychological health, Social relation and environmental health is affected by level of injury, ASIA grade(severity of neurological deficit) and complication(UTI, bed sore, spasticity).Special unit for spinal cord injury patient needed for active and productive lives in these patients in the community.

quality of life, traumatic spinal cord injury, quadriplegia, quadriparesis, paraplegia, paraparesis, Eastern India.