Rational drug design and synthesis of some 2-(2-phenyl1H-benzo[d]imidazol-1-yl)acetic acid derivatives as potential angiotensin receptor inhibitors

Volume 20 No 6 (2022)

Pravin S. Tajane, Ramesh L. Sawant

DOI: 10.14704/nq.2022.20.6.NQ22322

Abstract

Background and Objectives: After knowing the importance of benzimidazoles in various diseases, in present work, we aimed at preparing some 2-(2-phenyl-1H-benzo[d]imidazol-1-yl) acetic acid derivatives as potential angiotensin-II receptor inhibitors. Method: The designed derivatives were subjected for the calculations of Lipinski rule, Veber’s rule, ADME analysis, drug-likeness properties and molecular docking.

Keywords

Benzimidazole; ACE inhibitors; molecular docking, ADMET, in vitro, in vivo

Copyright © Neuroquantology

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in the Neuroquantology are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJECSE right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.