Toluene is an organic compound which has high volatile property at room temperature and widely used as a solvent. Considering the side effects of toluene exposure in long term for humans which people may experience hepatotoxic effect. This study aims to determine the relationship between the concentration and characteristics of toluene with malondialdehyde, cholesterol and diabetes in five selected industry in Surabaya which uses toluene as an organic solvent in their industry. This is an observational study with cross sectional design conducted at 5 industry in Surabaya. The selected industry are Osowilangun, Ketintang, Jemursari, Kalijudan and AUP. The population in this study were all workers exposed to toluene in the industry which is 90 of them in total. The research sample of 77 people was taken using the accidental sampling method. The variables studied in this research are Risk Qoutient, Toluene concentration, level of cholesterol, diabetes and malondialdehyde. No correlation exist between toluene concentration and cholesterol (p>1.0) and diabetes (p> 0.25). Significant correlation is seen between toluene concentration and malondialdehyde (MDA) (p<0.03). Conclusion: High level of toluene concentration doesn’t affect cholesterol and diabetes level. The level of malondialdehyde in RBC greatly influenced by the level of toluene exposure.

RQ Toluene, Toluene concentration, Diabetes, Cholesterol, Malondialdehyde