Background: Sepsis remains a serious problem in critically ill patients, and the mortality rate in patients with sepsis is increased dramatically when complicated by AKI. Therefore, accurate evaluation of AKI is essential in patients with sepsis. Objective: To improve the outcome of patients with sepsis by assessment of role of Cystatin C in comparison to serum creatinine in early detection of acute kidney injury in Emergency Department. Patients and Methods: This was comparative cross-sectional study included two groups, study group included 40 patients diagnosed with sepsis-induced acute kidney injury attending to the Emergency Department (ED) at Suez Canal university Hospital during from November 2020- July 2021 and Control group included 40 healthy individuals of same age group. The Patients was clinically assessed and managed according to the ABCDE protocol. Results: a value of 0.892 IU/L was found to be the best cut-off point for prediction of sepsis-induced AKI, with sensitivity = 100%, specificity = 92.5%. Conclusions: That serum Cystatin can be used as early predictors for AKI than serum creatinine in patients presenting with sepsis.

Acute Kidney Injury, Sepsis, Serum cystatin