Background: Vaginal bleeding prior to the 20th week of pregnancy is considered a threatened abortion. During the first two trimesters, around 25% of pregnant women have some vaginal bleeding, and 50% of these cases end in the pregnancy being lost. A spike in the mother's CA 125 level during pregnancy may result from disruption of the decidua or the fetal membrane's epithelial basement membrane, and this might be utilized as a predictor of a future spontaneous abortion. Objective: To assess serum CA125's predictive value in patients who are facing an abortion threat. Patients and methods: This was prospective case control study conducted on 80 ladies complaining of threatened abortion at Al-Zahaa University hospitals and Dikirnis General Hospital. Patients were split into two groups. Group A normal pregnancy, group B threatened abortion. Results: There were statistically substantial variation between control group and threatened abortion group as regards CA-125 p<0.001, as most cases (87.5%) in threatened abortion group had higher CA-125 >35.12 compared to control group. Serum CA-125 level can significantly determine patients with threatened abortion with sensitivity and specificity was 77.5% and 79.5% when the cutoff point was >35.12 IU/ml Conclusion: Serum CA125 is a valid and reliable predictor of pregnancy outcome in patient with threatened abortion, the levels are correlated to US finding, it has a sensitivity 77.5 & specificity 79.5 when cutoff point was >35.12 IU/ml.

Serum CA125, threatened abortion, pregnant women.