STUDIES ON BIMATOPROST, HOMOBIMATOPROST AND NORBIMATOPROST

Volume 20 No 22 (2022)

Naveen Reddy Seelam , Dr. Neeta Gupta

DOI: 10.48047/nq.2022.20.22.NQ10227

Abstract

The PG ocular hypertensives are PGF2 analogs where the α-side chain converted into either ester or amide functionality and in these the ω-side chain is modified with aromatic units. In previous chapter, we reported the development of a versatile key Intermediate (148) from racemic Corey lactone (140) and it can be elaborated in to variety of prostaglandins and their derivatives. As a demonstration of this general approach, we discussed conversion of key intermediate (148) in to (±) Bimatoprost (3), (±) Homobimatoprost (168) and (±) Norbimatoprost (172) and details are discussed in this article.

Keywords

Bimatoprost, Homobimatoprost, Norbimatoprost

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