Volume 20 No 22 (2022)
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Naveen Reddy Seelam , Dr. Neeta Gupta
The PG ocular hypertensives are PGF2 analogs where the α-side chain converted into either ester or amide functionality and in these the ω-side chain is modified with aromatic units. In previous chapter, we reported the development of a versatile key Intermediate (148) from racemic Corey lactone (140) and it can be elaborated in to variety of prostaglandins and their derivatives. As a demonstration of this general approach, we discussed conversion of key intermediate (148) in to (±) Bimatoprost (3), (±) Homobimatoprost (168) and (±) Norbimatoprost (172) and details are discussed in this article.
Bimatoprost, Homobimatoprost, Norbimatoprost
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