Piperazine belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections.The synthesis and anti-bacterial activity of a series of 6 different derivatives of Piperazine moiety incorporatingdifferent aromatic halides moiety with increased antibiotic effect with the minimum side effect. The conventional methodology was adopted to synthesize the titled compound from starting material 4-(piperazine-1-yl) benzonitrile treated with anhydrous potassium carbonate which gives 4-(piperazine-1-yl)benzoic acid it was halogenated and reacted with hydrazine hydrate gives 4-(piperazine-1-yl) benzo hydrazide it was reacted with carbon disulfide followed by ammonia gives the title compound 5-[4piperazine-1-ylyl)phenyl]-4H-1,2,4-triazole-3-thiol (Q1-Q6). The synthesized compounds were characterized by TLC, melting point, IR, 1HNMR, and Mass spectral data. All synthesized Piperazine derivatives were screened for anti-bacterial activity using DMFas a solvent against the organisms, S. aureus and E.coli. The compound Q2,Q4, and Q5 have shown very good activity against S.aureus at 100μg/ml whencompared with the standard drug Ciprofloxacin. The compounds Q2, Q5, and Q6 haveshowngoodanti-bacterialactivity.

Piperazine derivative, antibacterial activity, anthelmintic, S. aureus, E. Coli