SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLE DERIVATIVES (4-CHLOROPHENYL)-3-(4-AMINO) PHENYL)- 1H-PYRAZOL-4-yl) METHYLENE) HYDRAZINE BEARING THIAZOLE SCAFFOLDS AS POTENT ANTI-INFLAMMATORY AGENTS

Volume 20 No 9 (2022)

Neeraj Devi, Shobhit Srivastava, Bhumika Yogi, Udai Veer Singh Sara, Sanjay Kumar, Sujeet Kumar Gupta

DOI: 10.14704/nq.2022.20.9.NQ44334

Abstract

Recently, pyrazole derivatives have shown significant anti-inflammatory activity. Nonsteroidal anti-inflammatory drugs have the disadvantage of causing gastric irritation, gastric ulcer in the treatment of inflammation. Therefore, the present study focused on the synthesis and pharmacological evaluation of a series of novel pyrazole derivatives as anti-inflammatory agents.

Keywords

Anti-inflammatory, carrageenan induced paw edema model, dioxo-esters, pyrazole

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