Volume 20 No 12 (2022)
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SYNTHESIS OF NOVEL (E)-3-(1, 3-DIPHENYL-1H-PYRAZOLE-4-YL) PROPANOIC ACID DERIVATIVES AND BIOLOGICAL EVALUATION OF THEIR ANTI-INFLAMMATORY ACTIVITY
Dimple Pirgal , Konatham Teja Kumar Reddy, Vijayakumar B , Amrutha S , Akshay Kumar. U , K.V. Vismaya
Abstract
Five derivatives 3-(1, 3- substituted diphenyl-1H-pyrazole-4-yl-) propionic acidswere synthesized by
reduction of 3-(1,3-diphenyl-1H-pyrazole-4-yl-) acrylic acid in ethyl acetate was added in the presence of
20% palladium / charcoal with constant stirring. The reaction mixture was stirred for overnight and the
excess of ethyl acetate was distilled off under reduced pressure. The precipitate obtained was filtered,
dried and recrystallized from appropriate solventThe chemical structures of these compounds were
confirmed by means of Physical data and IR spectral data. The compounds were assayed for antiinflammatory activity.Among the compounds 4a and 4d showed significant anti-inflammatory activity, 4b
and 4e showed moderate anti- inflammatory activity
Keywords
Physical data, IR spectral data compounds, anti-inflammatory activity
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