SYSTEMS BIOLOGY, SINGLE NUCLEOTIDE POLYMORPHISM (SNP) AND GENE EXPRESSION ANALYSIS IN CORONARY ATHEROSCLEROSIS

Volume 20 No 18 (2022)

DR. SHOBHA MALVIYA, ABHINAV PRAKASH NAIR

DOI: 10.48047/NQ.2022.20.18. NQ88049

Abstract

We constructed models for over 660 genes, including 18000 ns SNPs, using an automated comparative modelling technique, and then compared and contrasted them with prediction methods based on structure and sequence. In addition to OMIM, which contains a minor allele frequency (MAF) of less than 0.01, another source of ns SNP data was the GWAS database. We have employed systems analyses by analyzing multi-omic studies of Coronary Atherosclerosis (CA) to decipher target pathways and underlying mechanisms.

Keywords

SNP, Structural, prediction, mutation, GEO, metabolomics pathway analysis.

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