Volume 20 No 10 (2022)
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Square-wave voltammetricdetermination of anticovid-19 drug remdesivirinpharmaceutical and real samples
Ziyad T. Al-Khateeb and MuthanaSalehMashkour
Abstract
Voltammetry was used to study the electrochemical behavior of Remdesivir at Glassy carbon electrode for the first time. The electro chemical behavior of (REM) was novelty diagnosed in three different ways through employment (CV, DPV and SWV) techniques.(REM) showed an irreversible oxidation peak at about +1.490 Vat Glassy carbon electrode, the scan rate study in the range 0.02–5 V/s indicates that the process is an electrode process that is completely irreversible and oxidation of REM on surface of GCE is diffusion controlled. Optimum operational parameters and the effects of experimental conditions to achieve the best experimental conditions for the voltammetric determination of REM at GCE,have been investigated.an excellent linear dependence of the SWV oxidative peak current on concentration of REM was observed in the range 10-100 ppm with limits of detection (LOD) and quantification (LOQ) of 0.059 and 0.19ppm, respectively .In addition, excellent recovery results were obtained for the analysis of REM in pharmaceutical injection and real samples. The proposed approach was effectively employed in the determination of REM in pharmaceutical and real sample. The novel proposed procedure is quick and affordable; sample preparation is not required.
Keywords
Glassy carbon electrode; SWV;DPV;Remdesivir; Covid-19.
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