Stereoselective Pharmacodynamics of Chiral Drugs with Special Reference to Ibuprofen

Volume 20 No 8 (2022)

Shiwani Sharma , DrAtulPratap Singh

DOI: 10.14704/nq.2022.20.8.NQ44722

Abstract

Chiral drugs constitute an enormous portion of the pharmaceutical industry. Nearly 56% of drugs manufactured today are chiral and most of them are marketed as racemates consisting of equimolar concentrations of the two enantiomers. Stereoselective pharmacodynamics and metabolism are the striking features of these chiral drugs, an interesting example of which is Ibuprofen 2-(4 isobutyl phenyl) propionic acid. It is a non-steroidal anti-inflammatory drug (NSAID) possessing analgesic, antipyretic, and antiplatelet (blood-thinning) properties. This article attempts to elucidate the stereoselective pharmacodynamics and toxicology of ibuprofen.

Keywords

10.14704/nq.2022.20.8.NQ44722

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