In the present research, we aimed to assess Gardenia resinifera's ability to prevent obesity in rats that had been given a high-fat diet (HFD). The methanolic extract of Gardenia resinifera (MEGR) was prepared and evaluated at various doses (50 mg/kg, 100 mg/kg, and 4 mg/kg), and its effectiveness was compared to that of the standard anti-obesity medication orlistat (20 mg/kg b.wt). Despite slightly increased food intake, MEGR treatment significantly decreased weight gain in HFD-fed rats. When MEGR was given along with HFD, serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL) were all significantly (P 0.05) decreased, while high-density lipoproteins (HDL) increased. Based on our findings, we show that MEGR has potential anti-obesity activity

Gardenia resinifera, high fat diet, progesterone, lipid level, obesity.