Furosemideis used as synthetic intermediates for the preparation of new heterocyclic derivatives biomolecules that possesses a pharmacological activity such as pyrazole, pyrrole and pyrimidine. The new derivatives synthesized compounds were confirmed using spectroscopic methods (FTIR, 1H-NMR spectral) and the physicochemical studies were investigated. The activity of these compounds was then screened as potential antibacterial against different types of pathogenic bacterial isolates and also as acute toxicity. The results displayed that some of prepared compounds were the most or equal powerful compared with Amoxicillin and Cephalexin as references drugs.

Furosemide, Synthesis, Characterization, Pharmacological Studies.