Initial diagnosis and prompt treatment of extra pulmonary tuberculosis continues to be a challenge in all over the world as well as India. First time, this study will prospect the role of LTA4H gene and may be establishing another candidate that influences the susceptibility to extrapulmonary tuberculosis in the North Indian population. This study will be the first report on LTA4H gene various diagnostic markers, expression of gene may validate as a prognostic factor in extrapulmonary tuberculosis. The associations between LTA4H SNPs levels. The diagnosis of extra pulmonary tuberculosis poses a special challenge, as it is often missed or misdiagnosed due to its atypical presentations and difficult to isolate M.tuberculosis due to the small number of organisms present at these sites. Subsequently the outcome of present study will reinforce possible use of LTA4H as biomarkers and the therapeutic utility for extra pulmonary tuberculosis. This study will be a step to deflate the diagnostic and therapeutic window to identify another risk factor (LTA4H) for extra pulmonary tuberculosis and will spawn new ways to safeguard and recuperate the health status of individuals and population groups. On RT-PCR, Extra pulmonary patients had lower expression of LTA4H compared to the controls.

LTB4GENE, ELISA, EPTB, RT-PCR