Coronavirus can also harm the vascular system and cause bleeding; this damage to the vascular system might be followed by dysfunctions in other body systems, therefore not a few COVID-19 survivors have experienced a stroke as a complication of COVID-19. Bleeding that occurs in the nose is a common condition that occurs as a result of a person's injury, allergies, or platelet levels that are declining. There are several simple ways to stop this bleeding, but for Indonesians betel leaf is a widely chosen traditional treatment. The subjects of experimental animal studies were divided into 4 groups. The results of the Anova test analysis showed that there was a significant difference in average platelet levels (p=0.05) in the 4 groups. The results showed that the lowest average thrombocytes and hematocrit levels were found in group 2, namely the group that was given LPS without being given betel leaf essential oil. The highest average thrombocytes and hematocrit levels were found in group 3, namely the group that was first given betel leaf essential oil, after which it was only applied LPS. Red Betel Leaf Essential Oil has the potential as an anti-bleeding in research subjects induced with infectious materials characterized by increasing average platelet levels and Hematocrit as components that play a role in the blood clotting process.

betel leaf essential oil, thrombocytes, anti bleeding