Objective: Interleukin IL-1RN 86bp VNTR upregulates in response to H. pylori infection, playing a central role in gastritis by inducing the production of many other molecules, such as proinflammatory cytokines, mediators, growth factors and adhesion molecules. Material and Methods: Fifty samples of the blood were obtained from patients and a safe control group, then DNA was extracted and analyzed for genotypes IL-86 with (PCR) and Gel electrophoresis using 2,25%, 2% the concentration of agarose was (respectively) investigated. Results: IL-86 mutations were detected in 50 percent of H.pylory infections patients, Although only 25% were observed in the control group, we noticed a substantial correlation between the genotype and the allele frequency and the P<0.05 group of H.pylory infections. Conclusion: IL-86 and H.pylory infections are associated with peptic ulcer.

Interleukin 1L- 86, H.pylory, Peptic ulcer, Polymorphism.