Volume 20 No 12 (2022)
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The Role of FUT1 Gene Expression in Acute Lymphoblastic Leukemia of Egyptian Patients: A single-Center CaseControl Study
Zainab . Atia , Ahmed N. Shaaban, Amal K. Selim , Elsayed I. Salim
Abstract
Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer globally, accounting for 25% of all cases, with a peak incidence between two and five years. The FUT1 gene is the principal precursor in ABO antigens formation on the red blood cell surface. Several studies reported the relationship between FUT1 gene expression and cancer. This study investigated the role of the FUT1 gene expression and its association with the ABO blood group phenotype in ALL patients from the Tanta cancer center, Egypt. Methods: A case-control study was conducted on 69 ALL Egyptian pediatric patients and 33 age-matched controls. The participants are divided based on ABO phenotyping into two main groups; O blood group patients and non-O blood group patients, with corresponding controls. 3 ml of venous blood samples on a sterile EDTA vacutainer were used for ABO phenotyping and FUT1 gene expression analysis by quantitative real-time PCR (qRT-PCR). Results: The FUT1 gene expression in the O blood group patients was higher than in the O blood group control (P=0.002), and in the non-O blood group patients (P<0.001). On the other hand, the relationship between the FUT1 gene expression, O blood group, and acute lymphoblastic leukemia risk using the simple and multiple logistic regression analysis showed that the crude (unadjusted) and adjusted odds ratios had no statistically significant association. Conclusion: FUT1 gene shows an overexpression within the O blood group phenotype; however, this overexpression is not found to be a potential risk factor for ALL in the studied Egyptian cohort
Keywords
ALL, FUT1 gene, ABO blood group, qRT-PCR.
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