Hyaluronic acid is a natural hydrocarbon and organic chemical compound found in the outer matrix of cells and tissues of the body, including skin, bones, eyes and cartilage. This substance is the basis of the connective tissue of the skin and is the strongest substance that absorbs moisture and nutrients for the skin, which is also effective in healing wounds. The human body contains approximately 15 grams of hyaluronic acid, which is present in all parts of the body, and one-third of it is decomposed and synthesized daily (decomposition of materials to produce new material or materials). More than 70% of the total body hyaluronic acid inthe skin is located because it is needed for the stability and maintenance of the internal matrix and many cell functions.One of the ways to heal skin wounds is to use fillers containing jelly. hyaluronic acid is external because these substances do not have an internal human origin and from animalsor bacteria, in many cases cause skin allergies and They have a short half-life. Efforts to preserve or increase the secretion of hyaluronic acid by human skin fibroblasts in preventing and eliminating the symptoms of skin aging.

Extracellular matrix, fibroblasts, skin aging, fillers are important.