There are about 40,000 spider species known till date. Spider bite is the most wide spreadlitch among people. Even though only sozme of them are toxin one the less delay in the treatment may lead to death. Particularly in endemic regions, the spider bites may pose hazard to the humans. Our objective in this review is to learn about most common poisonous spiders and to know the possible treatment. We here describe some of the venomous spiders depending on their morphology, post-bite symptoms and existing treatment options. Antidotes play a very crucial role in the management of certain spider venoms. This review is designed to focus on the role of antidotes, categories and its role in curing spider toxins. Spider venom toxins interact with the ion gated channels and biological activities in our body and show multiple effects. The severity of spider toxins gives rise to serious symptoms like cardiovascular disorders, chronic pain, inflammation and reproductive dysfunction. Thus a potential strategy has to be adopted for these toxins to act as therapeutics. Thus, treatment of spider venom should also involve providing supportive care to the patients and a number of synthetic antidotes available from various sources which should be readily accessible that provides immediate care to the patients.

Poison, anti-venom, toxin, antidotes, spiders, inflammation, therapeutics.