Background: Therapeutic plasma exchange (TPE) or interchangeably termed as plasmapheresis is a process involving extracorporeal removal of plasma from other components of blood and replacing it with physiological fluids. this procedure aimed at removes circulating antibodies, immune complexes and toxins from the blood. TPE has been effectively used in numerous disorders. Aim of the study: to assess TPE in our nephrology unit at Nephrology &Urology Minia University Hospital after the 1st year experience, including indications, doses, complications and outcome. Methods: This is a descriptive study, carried out through one year on patients who were treated using TPE; clinical data, investigations, number of sessions, type of used fluid for exchange, outcomes and complications were recorded and analyzed statistically. Results: Thirty seven patients were included to this study; 8 patients had Systemic lupus erytheromatosus (SLE), 4 patients had Thrombotic Thrombocytopenic Purpura (TTP), 4 patients had multiple sclerosis (MS),3 patients had Myasthenia Gravis (MG), 3 patients had nephrotic syndrome(NS) , 3patients had pre transplant elevated autoantibobodies,2 patients had posttransplant Immune mediated rejection , 2 patients had autoimmune encephalitis, 2patient had Heamolytic Uremic Syndrome(HUS),1 patients had covid -19 infection,1 patient had Staff man syndrome,1 patient had RH-Alloimmunization with pregnancy,1 patient had Thrombotic Microangiopathy(TMA) , 1 patient had neuromyelitis optica and 1 patient had Guillane Baree syndrome(GBs) . the total number of sessions of TPE Throughout this year were 192 session , As regard complications; the most common complication was chest infection , twenty nine patients were improved and 3patients showed no improvement while 5 patients un fortunately died during the treatment course of disease. Conclusion: TPE is a safe and effective adjuvant therapy for many diseases especially immune mediated disorders.

Plasmapheresis, Outcome, SLE, HUS, GBS.