The thiazole nucleus structure is essential unit in biologically important molecules, and various pharmaceutically active thiazole analogs have been conveyed., The versatility of thiazole unit demonstrated via the fact which it is an important part from penicillin corebesides some of its products that have appeared antibacterial (sulfazole), antifungal (abafungin), antihistaminic. The scope of this paper is synthesis of series new thiazole-amide derivatives via numerous types of reactions like (azotation reaction, coupling reaction, substitution reaction,…).Thiazole derivatives were confirmed via many spectral techniques (FT.IR,H.NMR,C.NMR)–spectrophotometric, other chemical characterization, with evaluation of formatted compounds as antifungal compounds.

Thiazole, Azo, Amide, Sulfide, Diethyl Malonate, Antifungal, Three Components Reaction.