Neuropathic pain caused by a lesion or disease of the somatosensory system. The somatosensory system allows for the perception of touch, pressure, pain, temperature, position, movement and vibration. Gabapentin is an anticonvulsive medication that originally saw use as a muscle relaxer and anti-spasmodic medication. It is also useful in certain types of neural pain control. Pregabalin (PGB) is a newer generation gabapentinoid which followed the use of gabapentin (GBP). This was secondary to limited efficacy in epilepsy as an adjuvant adjuvant antiepileptic drug, but also because of a series of case reports describing the benefits of gabapentin in the treatment of neuropathic pain (NeP). Amitriptyline is FDA approved medication to treat depression in adults. The Non-FDA approved indications are anxiety, post-traumatic stress disorder, insomnia, chronic pain (diabetic neuropathy, fibromyalgia).

Amitriptyline, Pregabalin, Gabapentine, Neuropathic pain